Cancer Metabolism

  1. K. Hardeman, C. Peng, B. Paudel, C. Meyer, T. Luong, D. Tyson, J. D. Young, V. Quaranta, and J. Fessel. Dependence on glycolysis sensitizes BRAF-mutated melanomas for increased response to targeted BRAF inhibition. Scientific Reports 7:42604, 2017. [Link to article]
  2. S. M. J. Rahman, X. Ji, L. J. Zimmerman, M. Li, B. K. Harris, M. D. Hoeksema, I. A Trenary, Y. Zou, J. Qian, R. J. C. Slebos, J. Beane, A. Spira, Y. Shyr, R. Eisenberg, D. C. Liebler, J. D. Young, P. P. Massion. The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer. JCI Insight 1:e88814, 2016. [Link to article]
  3. J. E. Hutton, X. Wang, L. J. Zimmerman, R. J. C. Slebos, I. A. Trenary, J. D. Young, M. Li, D. C. Liebler. Oncogenic KRAS and BRAF drive metabolic reprogramming in colorectal cancer. Molecular and Cellular Proteomics 15:2924-2938, 2016.  [Link to article]
  4. Y.M. Whang, S.I. Park, I.A. Trenary, R.A. Egnatchik, J.P. Fessel, J.M. Kaufman, D.P. Carbone, J.D. Young. LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small-cell lung cancer (NSCLC) cells. Oncogene 35:856-866, 2016.  [Link to article]
  5. C. S. Duckwall, T. A. Murphy, J. D. Young. Mapping cancer cell metabolism with 13C flux analysis: Recent progress and future challenges. Journal of Carcinogenesis 12:13, 2013.  [Link to article]
  6. T. A. Murphy, C. V. Dang, J. D. Young. Isotopically nonstationary 13C flux analysis of Myc-induced metabolic reprogramming in B-cells. Metabolic Engineering 15:206–217, 2013.   [Link to article]
  7. D. W. Strand, M. Jiang, T. A. Murphy, Y. Yi, K. C. Konvinse, O. E. Franco, Y. Wang, J. D. Young, S. W. Hayward. PPAR-gamma isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation. Cell Death and Disease 3:e361, 2012.  [Link to article]