Diabetes and Obesity

  1. Egnatchik, R. A., Brittain, E. L., Shah, A. T., Fares, W. H., Ford, H. J., Monahan, K., ... & J. D. Young. Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension. Pulmonary Circulation, 7(1), 186-199, 2017. [Link to article]
  2. C. M. Hasenour, D. E. Ridley, F. D. James, E. P. Donahue, B. Viollet, M. Foretz, J. D. Young, D. H. Wasserman. Liver AMP-activated protein kinase is unnecessary for gluconeogenesis but protects energy state during nutrient deprivation. PLoS ONE 12:e0170382, 2017. [Link to article]
  3. A. K. Leamy, C. M. Hasenour, R. A. Egnatchik, I. A. Trenary, C. Yao, G. J. Patti, M. Shiota, J. D. Young. Knockdown of triglyceride synthesis does not enhance palmitate lipotoxicity or prevent oleate-mediated rescue in rat hepatocytes. BBA-Molecular and Cell Biology of Lipids 1861:1005-1014, 2016. [Link to article]
  4. C.M. Hasenour, M.L. Wall, D.E. Ridley, C.C. Hughey, F.D. James, D.H. Wasserman J.D. Young. Mass Spectrometry-Based Microassay of 2H and 13C Plasma Glucose Labeling to Quantify Liver Metabolic Fluxes In vivo. American Journal of Physiology 309:E191-E203, 2015.  [Link to article]
  5. M.L. Wall, L.D. Pound, I. Trenary, R.M. O'Brien, J.D. Young. Novel stable isotope analyses demonstrate significant rates of glucose cycling in mouse pancreatic islets. Diabetes 64:2129-2137, 2015.  [Link to article]
  6. A.K. Leamy, R.A. Egnatchik, M. Shiota, P.T. Ivanova, D.S. Myers, H.A. Brown, J.D. Young. Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells. Journal of Lipid Research 55:1478-88, 2014.  [Link to article]
  7. R.A. Egnatchik, A.K. Leamy, D.A. Jacobson, M. Shiota, J.D. Young. ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload. Molecular Metabolism 3:544-553, 2014.  [Link to article]
  8. R. A. Egnatchik, A. K. Leamy, Y. Noguchi, M. Shiota, J. D. Young. Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes. Metabolism 63:283-295, 2014.  [Link to article]
  9. A. K. Leamy1, R. A. Egnatchik1, J. D. Young. Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease. Progress in Lipid Research 52:165–174, 2013.  [Link to article]
  10. Y. Noguchi, J. D. Young, J. O. Aleman, M. E. Hansen, J. K. Kelleher, G. Stephanopoulos. Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells. Molecular BioSystems 7:1409–19, 2011.  [Link to article]
  11. Y. Noguchi1, N. Shikata1, N. Nishikata1, Y. Hara1, J. O. Aleman, J. D. Young, S. Kurihara, N. Koyama, J. K. Kelleher, T. Michio, G. Stephanopoulos. Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice. PLoS ONE 5:e12057, 2010.  [Link to article]
  12. Y. Noguchi1, J. D. Young1, J. O. Aleman, M. E. Hansen, J. K. Kelleher, G. Stephanopoulos. Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis. Journal of Biological Chemistry 284: 33425–36, 2009.  [Link to article]

1Equal contributions.